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RNA therapeutics are expanding beyond liver-directed targets to muscle, brain, and heart tissues, enabled by breakthroughs in delivery technology. This expansion transforms RNA from a liver-specific tool into a broad platform for chronic disease management.

Impact: The ability to deliver RNA to multiple tissues opens up new therapeutic opportunities and could lead to the development of highly effective, less frequently administered drugs.

— from Novartis Strategy: Pure Play Focus and AI Integration · a16z Podcast· Feb 16, 2026