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GLP-1 therapies, while effective for weight loss, often cause significant muscle loss if not accompanied by adequate protein intake and resistance training. This leads to metabolic slowdown and rapid weight regain.

Impact: Highlights the need for integrated health strategies that combine pharmacological interventions with lifestyle modifications, creating opportunities for comprehensive health management services.

— from Function Health: AI, Testing, and Longevity Strategy · a16z Podcast· Nov 07, 2026