Crypto Navigates 'No Man's Land': Macro Shifts & AI Impact

Crypto Navigates 'No Man's Land': Macro Shifts & AI Impact

The Milk Road Show Nov 24, 2025 english 5 min read

Coinbase Institutional's David Duong unpacks crypto's volatile state, macro drivers, and AI's disruptive influence on markets and the broader economy.

Key Insights

  • Insight

    A customized global M2 money supply index, with a 110-day lag, projects a market inflection higher in December for crypto assets.

    Impact

    This suggests a potential recovery period for Bitcoin and the broader crypto market, driven by macro liquidity shifts. Investors should prepare for increased capital flow into risk assets.

  • Insight

    Federal Reserve policy, particularly regarding rate cuts and quantitative tightening, is the dominant driver of current crypto market volatility and sentiment.

    Impact

    The Fed's actions and communications directly influence the availability and cost of capital, making monetary policy a critical determinant of crypto asset valuations and short-term price movements.

  • Insight

    AI is both attracting investment capital away from crypto and potentially creating a K-shaped economic dynamic through white-collar job displacement.

    Impact

    This dual impact could alter the investor base and capital allocation trends for crypto, necessitating a re-evaluation of demand drivers and economic resilience.

  • Insight

    The historical four-year Bitcoin cycle is increasingly less relevant compared to current market factors like ETF outflows, institutional caution, and the broader risk environment.

    Impact

    Investors should shift focus from simplistic cyclical predictions to real-time indicators of institutional participation, market liquidity, and overall risk appetite to make informed decisions.

  • Insight

    Excessive leverage in the crypto system has significantly cleaned up, dropping from 10% to 4% of total market capitalization.

    Impact

    This deleveraging suggests a healthier market structure, reducing the risk of cascading liquidations and potentially forming a more stable base for future growth.

  • Insight

    Quantitative analysis in finance has been transformed by AI, allowing for significantly faster and more sophisticated model building and market insights.

    Impact

    This technological advancement enables a more data-driven and precise understanding of market dynamics, offering an edge to those leveraging AI tools for investment strategies.

  • Insight

    Due to government shutdowns creating a data vacuum, crypto markets are exhibiting heightened reliance on macro indicators and Fed commentary, leading to nebulous trading conditions.

    Impact

    The absence of reliable economic data amplifies the influence of central bank guidance and alternative data sources, increasing market uncertainty and the importance of macro forecasting.

Key Quotes

"Bull markets do not die of old age. They are slaughtered by the Fed."
"What I can tell you is that we run a regression analysis to say how long should that be? Generally, it seems that the highest correlation coefficient we get is associated with 110 days."
"100% a lot of people are hung up on the four-year cycle."

Summary

The crypto market, often a beacon of innovation and volatility, is navigating a "No Man's Land" as November 2025 draws to a close. Despite recent price declines, a nuanced analysis from Coinbase Institutional points to a potential December recovery amidst shifting macro tides and the pervasive influence of AI.

The Macro Undercurrents Driving Crypto

Coinbase's institutional research highlights liquidity as the paramount indicator for Bitcoin's trajectory. A customized global M2 money supply index, weighted towards key trading markets and with a 110-day lag, signaled a downturn in November but projects an inflection higher in December. This outlook is bolstered by crucial macro factors: the anticipated end of quantitative tightening on December 1st and increasing probabilities of Federal Reserve rate cuts. Initially, markets mispriced the December Fed meeting, but recent shifts in commentary and data vacuum conditions have led to a significant repricing, with a 75% chance now priced in for a rate cut.

Deconstructing Crypto's True Drivers

While many in the crypto space cling to the historical four-year cycle, experts suggest it holds less relevance than current market dynamics. Factors such as ETF outflows, the defensive posture of digital asset treasuries, and the broader risk environment impacting tech names are exerting a more significant influence. Notably, excessive leverage, which peaked at approximately 10% of the total crypto market cap between April and August, has substantially deleveraged to around 4%. This cleanup in positioning suggests a healthier, more stable foundation for potential recovery, with the $80,000 to $85,000 Bitcoin range appearing attractive for incremental buying, contingent on high-volume reclaims and positive stablecoin flow turns. Innovators like Bridge (instant stablecoin payments) and Reserve DTFs (decentralized token folios) address critical infrastructure needs for an evolving market.

AI's Disruptive Hand on the Economy and Investments

Artificial Intelligence presents a dual impact on the financial landscape and crypto specifically. Firstly, AI is actively attracting capital, drawing investment away from other risk assets, including crypto, as institutional and retail players alike seek opportunities in the burgeoning AI sector. Secondly, AI is profoundly affecting the broader economy, potentially creating a K-shaped recovery. Layoffs, even among white-collar workers and middle management (a demographic often associated with crypto investment), indicate that AI-driven productivity gains may disproportionately benefit corporations while displacing workers. From a quantitative perspective, AI has revolutionized market analysis, enabling rapid model building and sophisticated insights that were once prohibitively time-consuming.

Navigating the 'Age of Anxiety'

As the market grapples with a data vacuum caused by government shutdowns and relies heavily on private data for inflation signals, macro factors become unusually dominant. Investors are advised to pivot from historical assumptions to a data-driven approach, closely monitoring macro liquidity, Federal Reserve signals, and AI's evolving economic footprint. The prevailing environment demands strategic patience and a keen eye on the evolving interplay between global monetary policy, technological disruption, and market positioning.

Action Items

Implement a customized global M2 money supply index with a 110-day lag as a primary indicator for anticipating crypto market direction.

Impact: This will provide a forward-looking edge in understanding liquidity trends and positioning investment portfolios ahead of market inflections.

Closely monitor Federal Reserve statements and probabilities for rate cuts or dovish commentary, particularly around FOMC meetings.

Impact: Proactive assessment of Fed policy will enable rapid adjustments to investment strategies in response to significant shifts in monetary policy and market liquidity.

Analyze the impact of AI on capital flows between technology, AI-specific stocks, and crypto assets.

Impact: Understanding these capital reallocations is crucial for assessing crypto's competitive landscape for investment and identifying potential headwinds or tailwinds.

Prioritize current market data on ETF flows, institutional participation, and the broader risk environment over rigid adherence to historical crypto cycles.

Impact: This adaptive approach ensures investment decisions are based on contemporary market realities, reducing exposure to outdated or statistically unproven models.

Track systematic leverage ratios and open interest dominance (altcoins vs. Bitcoin) to gauge market frothy conditions and potential deleveraging risks.

Impact: Monitoring these on-chain metrics can help identify periods of excessive risk-taking and potential market corrections, enabling timely defensive positioning.

Integrate AI-powered tools and methodologies into quantitative research and market analysis processes.

Impact: Leveraging AI will enhance the speed and sophistication of market insights, leading to more robust models and potentially superior investment outcomes.

For re-entering markets or 'buying the dip,' wait for clear signals such as high-volume reclaims of key price levels and a definitive turn in ETF and stablecoin flows.

Impact: This disciplined approach minimizes risk during volatile periods, ensuring that capital is deployed based on confirmed market strength rather than speculative timing.

Tags

Keywords

crypto market analysis bitcoin price prediction coinbase institutional fed rate cuts AI impact on crypto global M2 money supply blockchain technology digital asset trends quantitative tightening market leverage